Endocrine Abstracts

Background: There is currently no agreed consensus for the optimization and titration of mineralocorticoid (MC) therapy in patients with primary adrenal insufficiency (PAI).Objective: To explore the relationship between serum (sFC) and urine (uFC) fludrocortisone levels and biochemically and clinically important variables, and to assess their utility in guiding and titrating MC replacement.Methods: Multi-centre, observational, cros...

Background: There is currently no agreed consensus for the optimization and titration of mineralocorticoid (MC) therapy in patients with primary adrenal insufficiency (PAI).Objective: To measure serum (sFC) and urine (uFC) fludrocortisone levels and explore their relationship with biochemically and clinically important variables (including treatment compliance) in order to evaluate their usefulness as markers to guide the MC replacement titration.<p ...

Background: Assays for parathyroid hormone (PTH) are not standardized and therefore method-specific reference intervals are necessary for interpretation of results. PTH increases with age in adults but age-specific reference intervals for the Abbott intact PTH (iPTH) assay are not available. It is challenging and resource intensive to derive age-specific reference intervals by direct method because, depending on number of age partitions, samples from a large n...